Causes and Effects of the Civil War Essay - 744 Words

nbsp;nbsp;nbsp;nbsp;nbsp;Did you know America’s bloodiest battle fought on their own soil was the Civil War? The Civil War was fought on American soil between the northern states and the southern states. Many causes provoked the war, which would affect the nation for decades to come. Slavery, the Missouri Compromise, and John Brown’s attack on Harpers Ferry, Virginia, were some of the many causes. In turn hundreds of thousands of soldiers died, the South’s economy was devastated, and the northern ideals flourished. nbsp;nbsp;nbsp;nbsp;nbsp;In the later 1700’s to 1863, slavery was an intricate part of the South. Slaves were needed for plantation work like planting, caring for, and harvesting crops to maintaining the land. After†¦show more content†¦The Missouri Compromise stated Missouri would be a slave state and Maine would be carved out of Massachusetts and created into a non-slave state. The Missouri Compromise really angered the North, contributing to the Civil War. nbsp;nbsp;nbsp;nbsp;nbsp;In May of 1856, Congressman Preston Brooks of South Carolina entered the nearly empty senate chamber and beat Massachusetts Senator Charles Sumner with a cane. Brooks felt violated by Sumner’s â€Å"Crime Against Kansas† speech, which provoked the retaliation. This attack spread the idea that violence might be able to solve the problem of slavery. In October 1859, abolitionist John Brown, led a violent attack. He and his band of 21 men and attacked the federal arsenal at Harpers Ferry, Virginia. They hoped to spark a slave rebellion that would end slavery, and in John Brown’s words, â€Å"purge this land with blood.† Brown’s attack was one of the final causes that sparked the Civil War. nbsp;nbsp;nbsp;nbsp;nbsp;When the Civil War finally concluded, thousands of American soldiers died fighting for what they believed in. The Confederate army lost a total of 258,000 soldiers and the Union army lost 360,000 soldiers. The loss of so many people immensely harmed the nation mentally and economically. Almost everybody had a family, relative, or friend that died in the Civil War. Half of the lives lost were farmers in the South, which devastated the South’s economy because these farmers were also consumers for theirShow MoreRelatedThe Causes And Effects Of The Civil War1564 Words   |  7 PagesThe causes and effects of the Civil War will be defined through the institution of slavery, the Kansas-Nebraska Act, and the military leadership of President Lincoln to resolve the uncompromising political position of the South/Confederacy. Lincoln’s â€Å"House Divided† speech will be an important primary source that defines the underlying resistance to the expa nsion of the slave states into new territories taken by the U.S. government in the 1850s. More so, the uncompromising and an increasingly militaristicRead MoreThe Causes And Effects Of The American Civil War1815 Words   |  8 PagesJames T. Vaughn Correctional Center September 9, 2014 The Causes and Effects of the American Civil War State Standard: H.4.A In 1860, Abraham Lincoln, a member of the anti-slavery Republican Party, was elected President of the United States (Hassler). Because his presidency was viewed by many southerners as a threat to the southern way of life, most southern states seceded from the Union and organized as the Confederate States of America (â€Å"Effects†). States that bordered the North and the South, suchRead MoreCause And Effects Of The Civil War Essay1078 Words   |  5 Pages Jean Park US History Period 4 23 September 2017 The Effects of the Civil War The civil war was between the Northern and Southern states, which were divided on the issue of slavery. The northern states didn’t want slavery to continue while the south wanted slavery to continue. This disagreement led to a five-year war from 1861-1865 leading to many social changes like the how the emancipation proclamation leading to the formation of the 13th, 14th, 15th amendments. Which allowed the African AmericansRead MoreEssay about Causes and Effects of the Civil War812 Words   |  4 Pagesthat in the Civil War, America lost the most men ever? After four years and over 600,000 American lives, the Union (North) prevailed in wearing down and forcing the Confederacy (South) to surrender. Eli Whitneys cotton gin, the Missouri Compromise, and the Dred Scott case contributed greatly to the Civil War. After the Civil War, the Southern economy was devastated with millions of homeless, while the northern economy boomed. Eli Whitney created one of the first causes of the Civil. In 1793 EliRead MoreEssay about Causes and Effects of the Civil War741 Words   |  3 PagesDid you know Americas bloodiest battle fought on their own soil was the Civil War? The Civil War was fought on American soil between the northern states and the southern states. Many causes provoked the war, which would affect the nation for decades to come. Slavery, the Missouri Compromise, and John Browns attack on Harpers Ferry, Virginia, were some of the many causes. In turn hundreds of thousands of soldiers died, the Souths economy was devastated, and the northern ideals flourished. InRead More Causes and Effects of the American Civil War Essay812 Words   |  4 Pagesthat in the Civil War, America lost the most men ever? After four years and over 600,000 American lives, the Union (North) prevailed in wearing down and forcing the Confederacy (South) to surrender. Eli Whitney’s cotton gin, the Missouri Compromise, and the Dred Scott case contributed greatly to the Civil War. After the Civil War, the Southern economy was devastated with millions of homeless, while the northern economy boomed.   Ã‚  Ã‚  Ã‚  Ã‚  Eli Whitney created one of the first causes of the Civil. In 1793Read MoreEllianne Heppler. Mr.David. Research Project. 05/08/2017.1700 Words   |  7 PagesDavid Research Project 05/08/2017 The Civil War and how it happened with A Little Twist! Think of the darkest place that terrifies people to their very core and then multiply that times 100. During the Civil War a lot of bad things happened from April 12, 1861 – May 9, 1865. On April 12, 1861 The Battle of Fort Sumter happened to be one of the least casualties battles. No one was hurt until a shot was accidentally misfired. That is what started the war. But that was the least of their worriesRead MoreWhat Caused The American Civil War1634 Words   |  7 PagesWhat caused the American Civil War from 1861 to 1865? There has been several different debates and disputes about the causes of the American Civil War. Historians have stated slavery was the primary cause of the American Civil War, while other historians have argued there were other causes and effects in conjunction with slavery. Research has shown all historians did agree upon the division between the North, known as the Union, and the South, known as the Confederacy, battled on the soil of theRead MoreTh e War Between The United States944 Words   |  4 PagesThe Causes to the War Between the States The Road of the United States in becoming a truly united nation has not been a path without turmoil. Many lives were laid down to form the structure of this country and fought for its right to freedom. One of the bloodiest conflicts in the United States’ history was the war between states or more commonly referred as the Civil War. This war leads to much unnecessary violence ridden battles that were precluded by many cases. The Civil War had many profoundRead MoreSyrian Refugees During The Syrian Civil War1573 Words   |  7 Pagesthe beginning of the Syrian Civil War three years ago, her life has not been the same. Her small school has been destroyed by explosions, and her uncle killed in a missile attack. By the summer of 2013 her family came face to face with the realities of war-- either die in Syria or risk everything by fleeing to Lebanon. To Dana’s family there was no choice, they had to flee. She has been living as a refugee in Lebanon ever since (Lewis). There are many causes and effects associated with Syrian refugees

Ilab Week 6 Math 221 Essay - 818 Words

Elementary Statistics iLab Week 6 Statistical Concepts: * Data Simulation * Discrete Probability Distribution * Confidence Intervals Calculations for a set of variables Mean Median 3.2 3.5 4.5 5.0 3.7 4.0 3.7 3.0 3.1 3.5 3.6 3.5 3.1 3.0 3.6 3.0 3.8 4.0 2.6 2.0 4.3 4.0 3.5 3.5 3.3 3.5 4.1 4.5 4.2 5.0 2.9 2.5 3.5 4.0 3.7 3.5 3.5 3.0 3.3 4.0 Calculating Descriptive Statistics Descriptive Statistics: Mean, Median Variable N N* Mean SE Mean StDev Minimum Q1 Median Q3 Maximum Mean 20 0 3.560 0.106 0.476 2.600 3.225 3.550 3.775 4.500 Median 20 0 3.600 0.169 0.754 2.000 3.000 3.500 4.000 5.000 Calculating Confidence Intervals for†¦show more content†¦The mean for the column â€Å"mean† is 3.56. It is very close to the parameter of interest but is not equal to it. You can calculate a confidence interval for the mean of the mean column, but a specific confidence interval would need to be provided. In that case, the confidence interval would be centered on 3.56, not 3.5. | 4. Give the mean for the median column of the Worksheet. Is this estimate centered about the parameter of interest (the parameter of interest is the answer for the mean in question 2) The mean for the median column is 3.6, which is close to the mean in question 2 but not as close as the answer in question 3. | 5. Give the standard deviation for the mean and median column. Compare these and be sure to identify which has the least variability? Standard Deviation of Mean= 0.4762Standard Deviation of Median= 0.7539The standard deviation of the Mean is smaller, which means all of the data points will tend to be very close to the Mean. The Median with a larger Standard Deviation will tend to have data points spread out over a large range of values. Since the Mean has the smaller value of the Standard Deviations, it has the least variability. | 6. Based on questions 3, 4, and 5 is the mean or median a better estimate for the parameter of interest? Explain your reasoning. The Mean seems to be the better estimate asShow MoreRelatedMath 221 Complete Course2525 Words   |  11 PagesMATH 221 COMPLETE COURSE A+ Graded Tutorial Available At: http://hwsoloutions.com/?product=math-221-complete-course Visit Our website: http://hwsoloutions.com/ Product Description PRODUCT DESCRIPTION MATH 221 COMPLETE COURSE, Discussions Week 1 Descriptive Statistics (graded) If you were given a large data set such as the sales over the last year of our top 1,000 customers, what might you be able to do with this data? What might be the benefits of describing the data? Week 2 Regression

Sop for Mis Free Essays

There is an old paradigm that says, â€Å"To stay where you are, keep running†. Today I realize how true it is because unless we keep track of the changes and advances being made we will be considered pariah. As I stand at the threshold of completing my undergraduate study, after carefully contemplating the various career options open to me I have decided to go in for graduate study that calls for personal commitment in fulfilling the crafts of independent research and dedicated involvement. We will write a custom essay sample on Sop for Mis or any similar topic only for you Order Now In turn, I shall get intellectual satisfaction and gratification of becoming a contributor of knowledge with research, and the greater personal rewards of memory and discovery. Now, on the verge of completion of my Under-Graduate Studies, I realize that my present knowledge would not suffice. I feel that unless one is erudite in his field, one cannot be fully satisfied. Any tryst with sciences, mathematics or any area that needed analytical thinking brought out the budding Engineer in me as I was not happy with just understanding a phenomenon but wanted a real time experience of the same. This interest in logical and computational thinking led me to take up Mathematics, Physics and Chemistry as my major subjects at the Pre-University level after completing my Schooling with 89%. I completed my pre-University education with 92. 3%. For my under graduate studies, I have opted for â€Å" Computer science and Engineering† in P S G College of technology, where I find my diligent study has brought home to me very strongly, that there is still a vast field that I must explore and master to achieve my goal of been the best. The economic ad technological liberalization that is taking place in my country would ensure that I would be able to use my expertise to make India a leader in the area of information science and technology. My expertise to the numerous Engineering subjects imbibed in me, an interest to pursue further education in this field. During my undergraduate course, I was exposed to various subjects which included software engineering, database technology, networking concepts which lead me to do my final year project work in networks which included designing, performance and security of particular network. I am also introduced to management based subjects like engineering economics and Industrial management where I gained knowledge and understanding of the basic management concepts, which made me secure good scores in those subjects. The essence of university education lies in the success of the symbolic relationship between the student and his department. It is with this in mind that I am looking forward to a long and rewarding relationship with your university. Your university is a confluence of people from varied culture, nationality, religion, race and ideology. I am sure that my exposure to these kinds of diverse influences would aid in the overall development of my personality and help me broaden my concept from the narrower confines of nationalism to internationalism. From the tremendous research options available here, I am confident that I will have the opportunity to work professionally with faculty on research projects and at the same time, I can make my research-work more meaningful. The hours of hard work that I put into excel in my education not only made me realize the beauty of attaining knowledge but also gave me the perseverance to look beyond and extend my boundaries, the time I have spent has only given me a brief glimpse of the vastness of knowledge, what I have seen has only aroused my curiosity and eagerness to explore the depths. I know that my goals are not mere wishes and I am aware that the path I am choosing is not a smooth horse ride. I understand that I have to put in painstaking hard work and compete with best in the world to achieve my goals. I am thoroughly prepared for it. To sum it up, I am prepared to go an â€Å"extra mile†-both figuratively and literally-add value to my qualification to realize my goals, I know that the competition is going to be tough but as it has been amply said. â€Å"Life’s battle does not always go to the stronger man, Sooner or later, the man who wins Is the man who thinks he can. † Finally I take this opportunity to thank you for enabling me to express myself and I look forward for my admission into the Masters in Management Information Systems(MS in MIS) program of your esteemed university. How to cite Sop for Mis, Papers

Business Intelligence Retrieve and Analyze

Question: Discuss about the Business Intelligencefor Retrieve and Analyze. Answer: Introduction Technology and acquiring information has been one of the most researched aspects which can help to save healthcare matters in this globe. To collect the needed information, certain technologies and software are required so as to make good use of the gathered information. Most healthcare facilities have embraced the use of business intelligence (BI). This refers to a type of application software which is created to collect, retrieve, analyze, modify and even report the data to the relevant parties so that necessary action can be taken (Chen, Chiang, and Storey, 2012, p.1170). BI tools can be used in the development of measurement goals to find validated metrics in various ways which include improving the quality of services provided. Embracing business intelligence software is very useful in developing those goals as it improves the service given by the healthcare facility as the collected information which is well analyzed can be very helpful in determining the best medical approach to be used among the very many of them. B.I tools can also be used to control costs. Use of business intelligence in many medical facilities is proving to be critical because apart from improving the quality of the services provided, it is also reducing the cost of receiving those services and this has contributed to improving health care in the whole country (Foshay and Kuziemsky, 2014, p.25). This reduction is because information is readily available and therefore the medics do not spend a lot of time and resources researching. This has been made possible because a lot of well-analyzed information can be accessed just by opening a software. BI has also improved health care efficiency and safety. BI tools can be used to streamline operations in healthcare facilities. This makes them provide more assured services, and this has helped in improving the safety of using complicated technology to cure various kinds of health problems, and this has assisted in developing measurement goals so as to find validated metrics. The data-centric perspective of business intelligence systems enables the organization to understand its capabilities and what it can do best so that it can maximize the benefits. It does so by collecting information from various sources and accumulating it in a central unit. After this, the data is transformed into different forms which can be very useful. The information is then integrated to the problem in question by the decision makers so as to ensure that decisions are more sound and helpful for solving various issues (Foshay and Kuziemsky, 2014, p.25). Process-centric, on the other hand, assumes that the organization as a system of well-integrated processes. The collected information is designed in a way that makes it form a sequence which has to be followed to solve a problem. Between the two perspectives, process-centric is the best. NorthShore University Health System used BI tools to treat hypertension. This disease May cause heart attack and stroke. They used this tools to identify undiagnosed hypertension patients and also identify hypertension patients who needed follow ups through the use of EMR. In conclusion, BI tools have helped a lot in improving healthcare facilities in many nations. It has assisted in supporting the complicated technology being used in hospitals nowadays. It has also helped in improving quality and efficiency in hospitals and also reducing the costs of treatment. Business intelligence should, therefore, be embraced by all able healthcare centers References Chen, H., Chiang, R.H. and Storey, V.C., 2012. Business intelligence and analytics: From big data to a big impact. MIS Quarterly, 36(4), pp.1165-1188. Foshay, N. and Kuziemsky, C., 2014. Towards an implementation framework for business intelligence in healthcare. International Journal of Information Management, 34(1), pp.20-27.

My Favorite Highway free essay sample

It seems that once in a great while, youll find out of perfect chance a song or an artist that really strikes a chord with you. You hear that first beat or singers pitch and its over. Your heart strings are already right in tune and you can sing along. This is what you find in My Favorite Highway, a lesser known but fast rising alternative band. From their catchier upbeat songs (Bad Habits and They Tried to Kill Chivalry, but We Brought It Back) to their sweet, meaningful piano and acoustic melodies (Calendar Marks and Bittersweet Life) theres something here for everyone. Every mood meets its perfect match through this band. Not only do they display amazing talent as musicians, but also as lyricists. From their most popular hit Bigger Than Love- If youve ever heard a beating heart, A rhythm for the songs were too afraid to sing Nobody here is perfectly fine, A delicate frame, a fragile design and from Calendar marks- Ive fallen victim to my greatest fear, The calendar marks that I lo st a whole year, Three-sixty-five, barely alive, Grace took her good natured time to arrive you can see that their lyrics are genuine and soulful but also contagiously singable. We will write a custom essay sample on My Favorite Highway or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Made up of 4 men from Fairfax, Virginia, the band was formed when the lead singer, Dave Cook, left college because he was feeling â€Å"uninspired† and decided to pursue his musical career with his cousin and bass guitar player, Will Cook. Full of promising talent, this band will likely be the next big thing. That is, if true talent is still recognizable and appreciated. Happy listening.

Path To Power Essays - Nazi Germany, Chancellors Of Germany

Path To Power Essays - Nazi Germany, Chancellors Of Germany Path To Power Filling three high-level voids caused Adolph Hitler to rise to power as the totalitarian dictator of Germany. With his country in the ferment left from World War One, groups at all levels of politics were looking for a savior. Hitler stumbled upon an awareness of his own charisma, saw the opportunities to usurp power, and pursued his assent. The key factors allowing his success were his rise through the German Workers Party, becoming Chancellor of Germany, and orchestrating the combination of the offices of president and chancellor. The first factor was Hitlers ordered membership in the German Workers party. In September, 1919, officers of the Munich Command suspected disloyalty among political groups when it came to the military, and they needed a spy. They chose Hitler because of his towering hatred for Jews and Traitors. His mission was to join the German Workers Party and help it grow. Shortly after joining the Party he learned that their goal was to discuss ways of creating a better Germany. Many of the members blamed the Jews and Marxists for the problems of Germany, but they had no plan or program to set things right. Working with this organization caused Hitler to discover something about himself. He never expected that he had a gifted ability to control and influence people for his gain through speech. The more he spoke, the more enthusiastic they became, and the more control he had over them. Hitlers emotions ignited the crowd. People lost control of themselves, trembling, sobbing, weeping, and howling. Men as well as women fainted and fell over in the aisles. They were bewitched. Hitler quit the military and decided to wield the German Workers Party as his weapon to become the dictator of Germany. The next stepping stone arose when President Paul von Hindenburg decided that the Nazis could no longer be kept out of the government and asked ex-Corporal Hitler to become Chancellor of Germany. He accepted and thus began the second phase to total power. Although Hitler was Chancellor he still couldnt mount his revolution from within. He needed additional Nazi seats in the Reichstag, similar to our Congress, to gain total power. In order to gain these seats he also needed an election along with a reason for the voters to support the idea of a dictatorship. He manufactured a crisis to accommodate his cause. One evening just before the elections, the metal dome of the Reichstag burst into flames. The fire was so tremendous all the firemen could do was watch it burn to ashes and scorched brick. Hitler pinned the blame to Communist leaders and gained over 17 million votes that secured 288 Reichstag seats. Hitlers plan was a success and he was ready to advance to being the totalitarian leader of Germany. The third and final phase of Hitlers conquest was set to begin. The Reichstag, consisting of only Nazi supporters Hitlers SS men allowed in, met on March 23 to vote on the Enabling Act which gave Hitler total power over their rights to suspend the constitution, change any law, and make any law. With the communist leaders banned from the Reichstag, the Enabling Act passed 441 to 91. Hitler moved quickly to strike anyone else who was a threat to him by killing them or putting them into concentration camps. On August 2, 1934, President Hindenburg died, and the military, pleased with Hitlers accomplishments, allowed Hitler to combine the offices of Chancellor and President, which included being commander in chief of the armed forces. Since all other political parties had been officially abolished, the Nazi flag became Germanys official flag, and every serviceman, from General to Private, had to swear an oath of obediencenot to Germany, but to Hitler himself. With this oath, The Fuhrers Third Reich was firmly established. With these three key strategies, Hitler became the totalitarian dictator of Germany and the horror of the Holocaust began in earnest. No one dare question his treachery. The prophecy of General Kurt von Schleicher was soon to be fulfilled. As he predicted, This corporal will destroy Germany and it will have a horrible end.

Have the policy tensions between free trade and environmental Essay

Have the policy tensions between free trade and environmental protection been adequately resolved - Essay Example Conferences have been held around the world to try and resolve these issues. Numerous policies have been implemented with the aim of resolving the persistent conflicts between the two global issues. An adequate resolution of the two elements would be beneficial to the world in attaining global sustainable development.4 The policies that need implementation should balance these aspects especially in underdeveloped and developing nations. For these nations to achieve impressive industrialization levels in the next decade, the tensions between these two aspects need to be resolved adequately. The existing issues There exist different trades which have a direct impact on the environment. The sale of animal products, like ivory, has had a considerable impact on wild life in many African countries. The sale of these products is encouraged by the free trade, provided by the international trade regulations. There has been a growing need to protect animal which provide ivory from poaching. Th e population of rhinos and elephants continues to decline as the years go by. Laws have been passed in many countries banning the sale of ivory. Early in the 1990s, Kenya imposed a ban on ivory trade within her territory. Majority of the ivory illegally acquired in Africa found its way in Asian market through the provisions of free trade5. In many Asian countries, ivory is used in the manufacture of local medicine. The growing trade, which existed, between the African countries and their Asian counterparts was significantly hampered by the regulation. A public auction was done for ivory which had been seized in Asia. The collection gained from the auction was distributed among the countries where the ivory was thought... From the research it can be comprehended that Free trade among different nation continues to be hampered by the efforts of environmentalists to protect the environment. These protection efforts continue to mitigate the growth of free trade especially at the international level. Over the past years, environmental policies have been set up to try and control the impact of free trade on the environment. There has been a proposal by some environmentalists to create â€Å"world environmental organization† to help coordinate international policies concerning the environment. Many environmentalists continue to push for the establishment of such an organization. This has been a source of the many conflict in existence between international free trade and environment protection policies. Conferences have been held around the world to try and resolve these issues. Numerous policies have been implemented with the aim of resolving the persistent conflicts between the two global issues. An adequate resolution of the two elements would be beneficial to the world in attaining global sustainable development. The policies that need implementation should balance these aspects especially in underdeveloped and developing nations. For these nations to achieve impressive industrialization levels in the next decade, the tensions between these two aspects need to be resolved adequately. The resolution of these tensions does not lie in the existing organizations which have been put in place to regulate the two global elements. The concerns of the elements always seem to be contrary to each other.

Abortion Final Essay Example | Topics and Well Written Essays - 1750 words

Abortion Final - Essay Example So questions arise like, is the mother who has aborted the child killer? Or, is the male partner of that woman equally responsible for this abortion/murder? Abortion is wrong at any stage, even at embryonic stage. If we will allow abortion for an earlier stage, then people will take advantage of this relaxation and will try to abort to baby even at a more mature stage which is called as fetus. So the main point of writing this paper is to argue that abortion should remain a crime except for a few genuine reasons. The term ‘abortion’ refers to those acts that are aimed at ending pregnancy. It also refers to forcing out the fetus or embryo form the womb of mother before it could be able to survive on its own: before complete child development that takes about 9 months in total after conception. If this happens accidentally, it is referred as ‘miscarriage’. In this paper we are going to present some common ethical dilemmas against abortion. Then later we will analyze those dilemmas. Giving birth to children is an important part of personal as well as social life. Nevertheless, there are people who decide to have an abortion due to various reasons (Graber, M. 1996). We are also going to discuss the methods that are generally used to abort a baby at different stages of the child development. We then have a look at historical and legislation frontiers. We will also discuss this issue in the light of normative ethics. The reason behind an abortion varies from society to society and culture to culture. Some societies hate girls and abort if the gender test shows that they are going to have a baby girl. On the other hand, many parents or partners change their minds to have a baby and abort the baby. In cases of rapes, rape victims are used to abort the baby because this act is wrong altogether. One child policy that prevails in China is also one of the reasons behind abortions. In some poor countries,

What is the evidence for the Big Bang Essay Example | Topics and Well Written Essays - 1750 words

What is the evidence for the Big Bang - Essay Example The primary focus of the essay is to capture the essence of the Big Bang theory and present to the reader evidence that proves that the Big Bang notwithstanding its flaws is still the most accepted theory that explains the evolution of our Universe. There is both, observational and mathematical evidence that corroborate the validity of the assumptions of the Big Bang Theory. To a curious mind gazing up from down below, the truth about the origin and evolution of the cosmos might still look like the hazy fleeting stars that sit millions of light years away. It was not just the tension-gripped scientists at CERN (European Organization for Nuclear Research) who tried to uncover the mysteries and validate the theories of the origin of the universe with the large hadron collider experiment. From the breakthrough Hubble made to the particle accelerator at CERN, the question of the origin and evolution of the Universe continues to remain pivotal in cosmology and the mind of every human bein g. One theory pertaining to the evolution and origin of the Universe that has emerged as a demigod in cosmology is the Big Bang Theory. Largely accepted, evidenced and validated the Big Bang theory has, for over a century now, been the centre point of almost all experiments and studies pertaining to this topic. The purpose of this paper is to establish the validity of the Big Bang through scientific evidence.... billion years ago, the Universe erupted from a single point of energy, wherein all matter that exists today was condensed in that tiny speck which exploded with an inconceivable force. This force sent outward splattering chunks of the Universe which created billions of galaxies and galactic bodies that exist in our Universe. The essence of the theory, however, is that the Universe has reached its current state by expanding rapidly from an extreme condition of density and temperature and to this day continues to expand and cool. Bound by human imagination and understanding it is difficult to comprehend what the Big Bang must have been like. It could have been nothing like hydrogen explosions today as there was no space or time prior to the Big Bang, in fact, space was created as the singularity expanded and formed the Universe. Rapid cooling caused atoms to form which later clouded together to form galaxies. The theory rests on the cosmological principle that the Universe is homogenou s and isotropic. Vesto Slipher, Lemaitre and Hubble were the founding members of the Big Bang Theory. 2.1. Misconceptions About the Big bang Theory It is commonly believed that there was an explosion that erupted and consequently created the Universe. However, evidence that has been collected and validated over the past century does not exactly prove or disprove this. The Universe can be imagined as a balloon continuously stretching to create space. Another common misconception pointed out by German cosmologist Rudolf Kippenhahn, regarding the theory is the negation of the concept of singularity. It is believed by some that there was a cosmic egg existing in space, however, there was no space or time before the Big Bang and both were in fact created after the Big Bang. Esteemed cosmologist

Effectiveness of Second Generation Tyrosine Kinase Inhibitor

Effectiveness of Second Generation Tyrosine Kinase Inhibitor Susmi Suresh Effectiveness of Second Generation Tyrosine Kinase Inhibitors in the Treatment of Chronic Phase Chronic Myeloid Leukaemia: a systematic review Abstract Background: Chronic Myelogenous Leukemia (CML), a cancer of the myeloid lineage, affects around 15 per 100,000 people per year in the UK. Tyrosine Kinase Inhibitor (TKI) oral therapy is used to target the causative BCR-Abl protein. Second-generation TKIs namely dasatinib and nilotinib are understood to be more potent than the first-generation prototype imatinib. However, cost-effectiveness is hindering the widespread use of second-generation TKIs. The patency of these drugs will expire in the immediate future and so, the prices of these are expected to fall. A clear understanding of the efficacy of the potent second-generation TKIs will aid decision-making bodies such as NICE UK to form guidelines on front-line drugs. This review aims to collect and examine evidence from current literature on the effectiveness of second-generation TKIs in the treatment of chronic phase CML. Method: A systematic search of major databases was carried out and the results were screened using specific inclusion and exclusion criteria. Five major randomised controlled trials were identified. Data extraction and risk of bias assessment were carried out using standardised forms developed specifically for RCTs by the Cochrane Collaboration. Quality assessment of the trials was performed using the CASP tool. Results: The five chosen RCTs were the DASISION trial, the S0325 trial and the SPIRIT 2 which compared dasatinib with imatinib, and the ENESTnd trial and the ENESTchina trial which compared nilotinib with imatinib. A participant pool of 2692 patients had a mean age of 61 years and similar features. A total of n=789 and n=697 patients were randomly assigned to dasatinib and nilotinib arms. Second-generation TKIs were associated with greater response rates in patients than imatinib; for example, dasatinib was associated with an odds ratio (OR) of 0.0803 (95%CI 0.0434 to 0.1489 Pin the S0325 trial, and nilotinib OR= 0.1772 (95%CI 0.1217 to 0.2581 Pin the ENESTnd trial. Conclusion: Current evidence points to a greater efficacy of second-generation TKIs, namely dasatinib and nilotinib, than imatinib. Adverse events (AEs) were reported for all three drugs. Due to the lack of a direct comparison between second-generation TKIs, the effectiveness of dasatinib over nilotinib could not be inferred. In order to aid bodies such as NICE to choose the most apt and safe TKI for use as a first-line treatment choice, it is suggested that future studies aim for a direct comparison. Toxicity data should also be generated to supplement this process. Introduction       Chronic Myelogenous Leukaemia (CML), a cancer of the myeloid lineage, accounts for 8% of adult leukaemias in the UK (1). This acquired genetic disorder causes the pluripotent myeloid stem cells in the bone marrow to undergo unregulated growth (2). A proliferative advantage thus results in patients having abnormally increased levels of serum leukocytes. The WHO ICD-10 classifies this disease as a malignant neoplasm with Philadelphia positive, t(9:22) (q34:q11) translocation and crisis of blast cells. With an annual incidence of 14.8 per 100,000 per year (3), leukaemia, along with its subtypes, is the twelfth most common cancer in the UK. The disease has a male predominance and its incidence increases with age (4). Although no causative environmental leukomogens have been identified, several studies have observed higher incidence in patients exposed to very high doses of ionising radiation (5). CML is often triphasic, with an initial chronic phase (CML-CP) followed by the advanced phases of accelerated (intermediate) phase and a final blast crisis- all with deteriorating laboratory profiles and clinical signs. Tyrosine kinase inhibitor (TKI) oral therapy has been used to extend the clinical course (particularly that of CML-CP). CML today is one of the fewest cancers which can be treated to attain 79% survival rates (6). Since the introduction of TKIs, there has been a significant reduction in mortality rates in the UK- from 1.5 per 100,000 in 2000, to 0.6 in 2010 (7); TKI-attributed mortality reduction is however debatable (8). Currently, imatinib is used as first-line treatment and is available to patients in the UK. Approved by the FDA in 2001, imatinib has been shown to be very effective in the treatment of CML. Prognosis is excellent with an increase in 5-year survival rates by 32% since its introduction (9). Hailed as the magic bullet against cancer (10), there have been several setbacks since introduction. Firstly, patients soon developed resistance. This was counteracted with the development of second-generation TKIs: nilotinib and dasatinib for imatinib-resistant (or intolerant) patients (2). Secondly, TKIs are deemed as one of the most expensive cancer drugs. For instance, in countries such as India where the generic forms are used, the cost difference for a month course, when compared to that in the UK, is an astonishing  £4200 and  £620 for imatinib and dasatinib, respectively (11). As a result, the availability of TKIs is strictly regulated by NICE. Whereas NICE recommends nilotinib as a first line drug if the manufacturer makes Nilotinib available with the discount agreed as part of the patient access scheme (PAS), dasatinib is neither a part of PAS nor is it recommended in CML-treatment (12). NICE explicitly comments on the low cost-effectiveness as the major reason for this despite it acknowledging these drugs to be more effective (13). It is to be reminded that NICE uses clinical as well as economic data to form its guidelines. Prices are expected to fall when the patency of TKIs expires in the future. For example, the patency for imatinib will expire in December 2016 in the UK. This may lead to possible alterations in the NICE recommendations and the use of second-generation drugs for first-line treatments may be favoured. Knowledge on the effectiveness of second-generation TKIs will help us shape the choice of appropriate TKIs in the future, when the pharmaceutical industry will be flooded with their generic versions. As such, this review aims to examine current evidence on the effectiveness of second-generation TKIs in the treatment of CML-CP patients. The molecular basics of CML CML is an acquired neoplasm resulting from the formation of an aberrant gene. In the myeloid stem cells of patients, the breakpoint cluster region (BCR) on chromosome 22 and the Abelson murine leukaemia (c-Abl) on chromosome 9 undergo a (9;22) translocation (Figure 1) . This results in the formation of the aberrant BCR-Abl fusion gene which is seen in 95% of patients (who are so referred to as Ph+ve). The BCR-Abl gene is translated into the leukemogenic protein p210BCR-Abl, an aberrant tyrosine kinase (TK) enzyme that is capable of constitutive activity. TKIs inhibit these aberrant TKs. c-Abl, the non-aberrant version of the gene, has a kinase domain which houses the ATP-binding pocket, an SH2 upregulating domain and an SH3 inhibitory domain. The kinase is strictly auto-inhibited and shuttles between the nucleus and the cytoplasm. However, the BCR-Abl TK is localised in the cytoplasm and this is implicated in its constitutive TK activity (Figure 2). In the cytoplasm, it undergoes auto-dimerisation which activates the enzyme by triggering structural alteration. c-Abl works by phosphorylating the Grb2 substrate protein. This activates the SoS effector molecule which facilitates the conversion of Ras-GDP to Ras-GTP. This further activates Raf due to which MEK1/2 is phosphorylated. As a result, ERK, a critical regulator of Cyclin D is also activated. ERK induces the synthesis of Cyclin D, which along with cdk4, determines whether the cell cycle is allowed past the G1 Restriction point. Once past this checkpoint, cell cycle cannot be reversed and so, the resultant daughter cells are produced. Cyclin D phosphorylates retinoblastoma (Rb), which in its inactive state is unphosphorylated and attached to E2F (a transcription factor), and releases E2F. This allows the cell to enter into the S phase (14) to begin DNA replication. Expression of the BCR-Abl gene upregulates proliferation by constitutively activating the Ras signalling pathway (Figure 3); cyclin D is continuously produced. BCR-Abl expression also facilitates anti-apoptosis and disrupts adhesion (Figure 4). A disrupted adhesion to stromal cells and the extracellular matrix reduces the regulatory effect transmitted via focal adhesions (15). Also, clonal expansion is aided by the evasion of apoptosis. Thus, uncontrolled Ras signalling, upregulated anti-apoptosis and disrupted adhesion are understood to lead to the ultimate manifestation of CML   (16). TKIs inhibit these aberrant tyrosine kinases. Imatinib is a competitive antagonist of the tyrosine kinase domain of BCR-Abl (16). Tyrosine kinases exist in active or inactive states, depending on whether the activation loop located on the C-terminal domain is open or closed (Figure 5).In the inactive state, the activation loop is closed and folds towards the ATP-binding pocket (17). Imatinib and nilotinib bind to the inactive conformation (Figure 6) whereas dasatinib binds to both conformations. Several studies have shown second-generation TKIs to be more effective in treating chronic phase CML (18-20). One such study showed that dasatinib was 325-fold more effective than imatinib at inhibiting BCR-Abl in vitro; this is attributed to its ability to bind to multiple conformations (21). Methods (Appendix A) Results Five randomised controlled trials were identified (Table 9). These included three trials- DASISION, Second Phase S0325 and SPIRIT 2- that compared dasatinib with imatinib and two trials- ENESTnd and ENESTchina- that compared nilotinib with imatinib. All of these together show better outcomes for CML-CP patients treated with second-generation TKIs. The primary end point of all these trials, except DASISION and SPIRIT 2, was MMR rates at 12 months. The DASISION trial looked at CCyR at 12 months. The primary endpoint of SPIRIT 2, the largest dasatinib trial, is event-free survival at 5 years. This will only be measured in March 2018 but nevertheless, secondary outcomes such as CCyR rates at 12 months have been published. All other studies also measured CCyR at 12 months as the secondary outcome. The Dasatinib versus Imatinib Study in Treatment-Naive CML Patients (DASISION) (22) The study aimed to find whether patients given dasatinib had a higher CCyR by 12 months of treatment. CCyR and MMR at 12 months were compared for both drugs and it was concluded that dasatinib may improve long-term outcomes in CML-CP patients due to its shorter response time than imatinib (Table 9; Appendix B: CCyR and MMR measurement methods and scale). Considered as a landmark study, these results proved to be pivotal in accepting dasatinib as a standard second-generation TKI. A 5-year follow-up was conducted to understand whether dasatinib can be continued to be considered as a standard therapy for CML-CP patients. The results (Table 10) supported the original finding (23). The Second Phase S0325 Intergroup (South Western Oncology Group, East Cooperative Oncology Group, Cancer and Leukemia Group B and NCI Canada Clinical Trial Group) Trial (24) The study aimed to compare the response rates for dasatinib- and imatinib-treated patients. Following standard clinical measurement of CCyR rates (Appendix B), dasatinib was found to produce more early short-term cytogenetic and molecular response rates (Table 9). However, the study also noted Grade3-4 toxicities in 58% patients in the dasatinib arm, compared to only 35% in the imatinib arm. Toxicity data were not reported in DASISION or SPIRIT2. ST1571 Prospective International Randomised Trial (SPIRIT 2) (25) CCyR response rates for dasatinib- and imatinib-treated patients were compared. The study observed an increased response rate for dasatinib compared to imatinib (Table 9). With these results, the study concluded that dasatinib was favoured in CML-CP treatment. Evaluating Nilotinib Efficacy and Safety in Clinical Trials- Newly Diagnosed Patients (ENESTnd) (26) A multicentre three-arm trial, this aimed to assess the efficacy and safety of nilotinib compared with imatinib. Two groups of patients given different doses of nilotinib were compared to those treated with the standard imatinib dose. CCyR was found to be higher in both nilotinib arms, compared to the imatinib arm (Table 9). The study thus concluded that nilotinib at either doses produced a clinical response better than imatinib. A 5-year follow up (Table 11) aimed to evaluate the long-term outcomes in patients taking nilotinib; MMR and 5-year overall survival (OS) rates of these patients were examined (27). Patients treated with the higher dose of nilotinib were found to have more AEs. Despite this, due to the short-time with which MMR and CCyR were achieved, the study concluded to recommend nilotinib at 300mg twice daily over imatinib. Current evidence provided by DASISION trial and the works of Quintas-Cardama A et al., 2009 and Hochhaus et al., 2009 were referred by the researchers. These directly link shorter response time with increased long-term benefits and reduced risk of progression (28, 29). Evaluating Nilotinib Efficacy and Safety in Clinical Trials- China (ENESTchina) (30) The trial, conducted in Chinese patients, aimed to observe MMR rates at 12 months in nilotinib and imatinib treated patients. Also, conclusions on whether genetic and ethnic factors affect response to treatment were drawn using the results. Whilst MMR showed a similar pattern as seen in the original ENESTnd trial, CCyR at 12 months for the nilotinib arm was lower than the imatinib arm by 3.6%. Since CCyR at 6 months showed an increased rate for nilotinib (66.4% vs 57.1% for imatinib), the study noted this inconsistency to be favouring nilotinib. Previous studies were cited to have observed early CCyR indicative of better response (31, 32). Thus, it was concluded that nilotinib was more effective.   Study Intervention Dosage n Males (%) Median age Lost to follow up (%) CCyR at 12 months MMR at 12 months DASISION Dasatinib 100mg daily 259 56 46 15 83% (95%CI 78-88; P-value 0.01) MMR3x 46% (95%CI 40-52 P-value Imatinib 400mg daily 260 63 49 19 72% (95%CI 66-77; P-value 0.01) 28% (95%CI 23-34; P-value S0325 Dasatinib 100mg daily 123 60 47 na* 84% (95%CI 74-92; P-value 0.040) MMR3 59% (95%CI 48-68; P-value 0.059) Imatinib 400mg daily 123 63 50 na 59 % (95%CI 56-80; P-value 0.040) 44% (95%CI 34-55; P-value) SPIRIT 2 Dasatinib 100mg daily 407 61.4 53 0 53.4% (P-value MMR3 58.4% Imatinib 400mg daily 407 59.2 53 0 41.6% (P-value 43.1% ENESTnd Nilotinib 300mg twice daily 282 56 47 16 80% (P-value MMR3 44% (P-value Nilotinib 400mg twice daily 281 62 47 18 78% (P-value 43% (P-value Imatinib 400mg daily 283 56 46 21 41.6% (P-value 22% (P-value ENESTchina Nilotinib 300mg twice daily 134 67.9 41 na 77.6 (66.4 at 6 months) 52.2% (95%CI 43.4-60.9; P-value Imatinib 400mg daily 133 60.9 39 na 80.5 (57.1 at 6 months) 27.8% (95%CI 20.4-36.3; P-value Table 9 Study Characteristics; (*na= not available; x See Appendix B: Parameters for measuring effectiveness of TKI) Study Intervention Dosage MMR MMR4.5x 5-year OS (HR 1.01; 95%CI 0.58-1.73) Adverse Events* : Drug-related Pleural Effusion DASISION 5-year Follow-up Dasatinib 100mg daily 76 (P-value= 0.0022) 42(P-value= 0.0022) 91% 28% Imatinib 400mg daily 64 (P-value= 0.0251) 33(P-value= 0.0251) 90% 0.8% Table 10 DASISION 5-year Follow-up Study (*No new adverse events were reported; x See Appendix B: Parameters for measuring TKI effectiveness) Study Intervention Dosage MMR4.5 OS Overall Adverse Events ENESTnd 5-year Follow-up Nilotinib 300mg twice daily 54% 93.7% (95%CI 90.8-90.6) 32.9% Pleural Effusion: 1.8% Nilotinib 400mg twice daily 52% 96.2% (95%CI 93.9-98.5) 41.4% Pleural Effusion: 0.7% Imatinib 400mg daily 31% 91.7% (95%CI 88.3-95.0) 32.7% Pleural Effusion: 1.1% Table 11 ENESTnd 5-year Follow-up Study Discussion The pooled data from 2692 patients show that the second-generation TKIs were more effective than the first-generation TKI imatinib. The results from the three RCTs which compare dasatinib with imatinib give an average absolute risk reduction (ARR) of 26.0%; for nilotinib, average ARR is 24.6% (Table 12). Together, second-generation TKIs produce a very promising complete cytogenic response in 253 per 1000 patients per year. As a comparison, a Cochrane systematic review conducted by Aguilar MI et al., 2005 to understand the efficacy of oral anticoagulants in preventing ischemic heart attacks, collected data from five RCTs with a pool of 2313 patients. This showed that warfarin gives an ARR of 4.05% and so the use of warfarin as a common anticoagulant was continued to be supported (33). Hence, a very high combined ARR of 25.3% shown in this review emphasises the potency of second-generation TKIs in treating CML-CP. With continuous treatment using these TKIs, remission can be attained. à ‚      RCT Intervention Odds Ratio Absolute Risk Reduction (ARR %) ARR per 1000 population (per year) DASISION Dasatinib 0.5242 (95%CI 0.3437 to 0.7997 P=0.0027) 0.11089 (11.1%) 110.9 S0325 Dasatinib 0.0803 (95%CI 0.0434 to 0.1489 P 0.55409 (55.45%) 554.1 SPIRIT 2 Dasatinib 0.6217 (95%CI 0.4713 to 0.8203 P= 0.0008) 0.11825 (11.8%) 118.3 ENESTchina Nilotinib 1.1871 (95%CI 0.6578 to 2.1426 P=0.5691) -0.04282 (-4.28%) -42.82 ENESTnd Nilotinib (300mg) 0.1772 (95%CI 0.1217 to 0.2581 P 0.40358 (40.4%) 403.6 Nilotinib (400mg) 0.2025 (95%CI 0.141 to 0.2925 P 0.37672 (37.7%) 376.7 Table 12 Data processed by the review author Dasatinib Trials The DASISION trial was industry-sponsored and as such, the results are to be approached with caution due to a possible risk of bias. However, the largest dasatinib trial, SPIRIT 2 also shows a very similar ARR of 11.8%. Moreover, the European LeukemiaNet Panel used the results from the DASISION and other similar studies to set the 2013 guidelines in the management of CML-CP (34). Hence, the results are widely acknowledged by the scientific community. However, due importance must be given to toxicity data generated from these studies whilst interpreting the results. Whilst DASISION stated that adverse events (AEs) for both arms were similar, toxicity data were not explicitly reported in DASISION and SPIRIT 2 studies. The S0325 trial addressed this issue (See Results). The team suggested that the choice of TKI should only be made based on a patients individualised risk of progression, pre-existing comorbidity and compliance (24). With reference to this, the 5-year follow-up of DASISION emphasised that there were no new events reported outside of the initial 12 month period (23). Nonetheless, both teams reiterated the quick response of dasatinib in treating CML-CP as an indication of its greater efficacy. However, this increased effectiveness becomes equalised in the long-term, with both dasatinib and imatinib producing similar overall survival rates five years post-treatment (23). Nilotinib Trials Compared to dasatinib, the risk of AEs was only slightly increased in nilotinib patients. Unlike the other RCTs, ENESTnd trial observed imatinib-treated patients to have a high risk of AEs. Nausea and diarrhoea were reported in a very high percentage of patients- 41.1% and 46.1% respectively. The molecular mechanisms of AEs are not currently understood and no studies have been trialled in patients to quantify and assess TKI-related AEs. Hence, a clinically-relevant conclusion was not drawn from these results. Limitations One main factor limiting this review is the absence of direct comparative studies between dasatinib and nilotinib. The S0325 trials observed that the standard dose of dasatinib produced more AEs than imatinib and the ENESTnd trial showed that the higher dose of nilotinib produced more AEs than imatinib. However, these observations alone cannot be used to highlight nilotinib over dasatinib. Another limitation is the possibility of selection bias. Currently, numerous on-going clinical trials worldwide aim to compare the various TKIs. However, much data is yet unpublished. These could not be included in this review due to the lack of an appropriate critical appraisal tool, other than the CASP tool used in this review, with more rigorous criteria. Despite these, conclusions drawn from a large pooled study population of 2692 patients remain reliable. Nonetheless, inconsistencies on both efficacy and AEs data were present when comparing the five trials. The ENESTchina trial observed a better result with imatinib at twelve months than nilotinib (OR= 1.1871; 95%CI 0.6578 to 2.1426 P=0.5691). Additionally, the ENESTnd trial reported imatinib to be associated with higher AEs than dasatinib. However, the pooled data show a greater efficacy of dasatinib and nilotinib than imatinib. Dasatinib is also associated with more AEs than standard dose nilotinib and imatinib. The comparability of ENESTchina to other trials could be questioned. Patients from all ethnicities was a definite inclusion criterion and hence this study could not be excluded. The primary aim was to evaluate the efficacy and safety of nilotinibà ¢Ã¢â€š ¬Ã‚ ¦vs imatinibà ¢Ã¢â€š ¬Ã‚ ¦ (in) patients with newly diagnosed P

An Image of Truth :: Essays Papers

An Image of Truth Plato teaches that reality is to be found in universal â€Å"forms.† Images of objects are therefore pale imitations of reality: that is, at least twice removed from the truth. Nevertheless, Jane Austen in Pride and Prejudice suggests that the image of a person can offer true insights that the actual person might not. In her very first meeting with Mr. Darcy, Elizabeth is left â€Å"with no very cordial feelings towards him† and after spending â€Å"four days in the same house with him† she still â€Å"think[s] him very disagreeable† (9, 53).1 Even after Mr. Darcy has directly and blatantly declared his love for Elizabeth she cannot consider him favorably and exclaims â€Å"I have never desired your good opinion† (125). Just to walk with him in the park â€Å"seem[s] like willful ill‑nature or a voluntary penance† (120). However, Elizabeth’s feelings for Darcy change after she views the portrait of him at Pemberley. She d evelops a â€Å"more gentle sensation toward the original† after seeing the painting and may even consider Darcy’s â€Å"regard with a deeper sentiment of gratitude than it had ever raised before† (162). Elizabeth needs the indirect image of Darcy in this portrait to view the man himself more accurately than she can when she faces him in person. The painting offers her time to contemplate Darcy’s true character. Furthermore, the frozen image creates a distance from which Elizabeth may consider Darcy without the interference of her intense emotions. When Elizabeth is face to face with Darcy, she must engage him in conversation, but when she examines the portrait, she does not have to speak: she can look at the painting for â€Å"several moments†¦in earnest contemplation† and even â€Å"return to it again† before leaving (162). Socially, great importance is placed on witty dialogue and polite conversation. At the first ball, the newly arrived Mr. Darcy is criticized for his reserve; rather than extend himself to form new acquaintances, he speaks only â€Å"occasionally to [a lady] of his own party† (8). Yet by refraining from conventional conversation, Mr. Darcy is able to form sound opinions. When he â€Å"wish[es] to know more of [Elizabeth]† he first â€Å"attend[s] to her conversations with others† before directly engaging her in dialogue (17). He even advises Elizabeth to take her time in getting to know him, urging â€Å"I could wish, Miss Bennet, that you were not to sketch my character at the present moment†¦the performance would reflect no credit on either.

Media violence and society

The influence of media is characterized by theories about how mass media shape a person’s behavior and thinking.   The development of media is further evidenced by the emergence of the Internet and DVDs, which sophisticated the way an individual receives information from media worldwide (Curran and Seaton, 1988). The most well-known premises about the influence of media on the society are those related to theories having a passive audience. An example of this theory is the hypodermic needle model, which compares media with an intravenous injection, with the media message being the matter transferred.   The explanation is that the information being transmitted by media is voluntarily and obediently received by the audience.   This, however, is still dependent on the interfering factors that changes the way an individual perceives the message (Weaver and Carter, 2006). Another example is the inoculation model, which induces a long-term influence on people by making them resistant or immune to the message conveyed by the media.   Here, a person becomes somewhat desensitized by a violent film for example, making him able to tolerate the same degree of violence once encountered again (Curran and Seaton, 1988). Different theories have different fall backs and limitations but nevertheless, they can help explain how media influences the attitude of an audience.   The theory that violent media result to violence on the part of the audience, especially the younger ones, is also deficient of a logical scientific foundation.   This is the main reason why it is regarded more as a hypothesis rather than a theory (Potter, 1999). Whether or not violent media has bad influences on the society is an argument usually raised when media effects are being taken into consideration.   This has also been used widely as a topic on debates, with the usual premise that violent media indeed have bad effects on its audience, which in fact is true. This argument is supported by many researches which relate the media of violent nature to the aggressiveness and obnoxious behavior of viewers or listeners, especially the younger generations.   A study was done using an inflatable clown which was introduced to two groups of children.   One group was accompanied by an adult who ignored the clown and settled playing with the other toys.   The children also ended up playing quietly and calmly with the toys other than the clown. The other crowd was grouped together with an adult who executed several aggressive moves on the inflatable clown, such as kicking and punching.   The children imitated the moves done by the aggressive adult onto the clown when left alone with the toys.   This can be related to the effect of media since the children can see and consequently imitate the actions of the adults (MAN, 2007). Another study was done after the release of the movie A Clockwork Orange in 1971.   The lead role in the film, which also depicts a hero, was both woman-beater and a rapist.   The film ended up a controversy when gangs started to copy the character of the lead actor, resulting into many rape and death cases.   The director, Stanley Kubrick, was also very sorry that he directed the violent movie. He banned the movie to prevent further criminal cases and for his family’s protection against death threats since he was being held partially accountable for the incidences.   These are just a few examples that violent movies are being imitated by the audience (Barker and Petley, 1997). A research was performed in 1956 to demonstrate the effect of violent media in 24 children.   A dozen watched a violent episode of Woody Woodpecker, while the other half watched a non-violent one entitled The Little Red Hen.   When the children were observed during playtime after watching TV, those who watched the violent show were the ones most likely to fight with each other and smash their toys (Potter, 1999). In 1963, three professors conducted a study which involved 100 children to determine the effects of violence in reality, television, and cartoons on the subjects’ behavior.   The entire population was divided into four, wherein the first group was allowed to witness a real adult shouting at an inflatable doll while at the same time beating it with a toy hammer.   The second twenty five preschool children were shown the same incident on TV, while the third group was allowed to watch a cartoon showing the same event. The fourth was group served as the control, and did not watch any.   All the groups were then opened to annoying circumstances.   All the first three groups exhibited a significantly higher level of aggressiveness as compared to those who were in the fourth group.   The group that watched the incident on TV was as violent and aggressive as those who watched it in the real scenario (Curran and Seaton, 1998). The Kaiser Family Foundation likewise conducted a study in 2003 showing that 47 per cent of parents have reported that their children have, at one point in their lives, have mimicked the violent actions portrayed by a character on TV.   However, the organization reported that children are still more inclined to imitating the positive behaviors they observed.   The violence in cartoons, which is commonly characterized by the use of bomb, guns, and deformed bodies, can make children believe that a person can not be hurt by such violent actions which can cause death and accidents when done in the real world. Furthermore, children often imitate the actions of their super heroes as seen on cartoons and other TV shows.   They sort of internalize what they see and formulate their own script which they would resort into when they encounter trouble or something harsh, making violence a way to solve problems (Healthyminds.org, 2007). Due to the negative psychological effects of animated shows on the target viewers, many cartoons were censored and animators protested because their creations eventually became boring.   They stated that many children who watch such cartoons are not negatively affected in terms of attitude and behavior, and that no scientific evidence was established to link the negative behavior of the audience to the violent media (Barker and Petley, 1997). The majority is being considered in all cases of violent media effects, and it should always be remembered that the subconscious of the audience can still be influenced, regardless of the subject’s age, inert attitude and personality, and moral beliefs (Weaver and carter, 2006). It is a fact that even adults can be negatively influenced by violence in media.   News containing violent reports can be exaggerated in the delivery of information.   This can lead to the people being scared and overreacting to the reported situation, which they can also associate to whatever it is that is happening in their immediate environment.   They might feel unsafe even if they are protected (Barker and Petley, 1997). It should always be remembered that parental guidance is an important factor that can alter an individual’s, especially a child’s, perception of violent media.   This intervention can significantly lessen the effects of violent media on society.   This should have a stronger influence on the audience than the violent media itself.   With all the researches and studies mentioned, it can be concluded that violent media indeed has bad influences on the society.   This is particularly true to children and adolescents who received less guidance from their parents during their childhood. Violent media can cause psychological disturbances and aggressiveness in people when faced with frustrating and provoking situations.   It can also mold children to be destructive when they grow up.   As true as there are people who remain unaffected by violent media, majority can be said to agree with the premise since each and every one in the society, regardless of personality and age, can be subconsciously affected by violent media in some way. Reference List Barker, M. and J. Petley. (1997). Ill Effects:The Media-Violence Debate. NY: Routledge. Curran, J. & Seaton, J. (1988). Power without Responsibility. UK: Press and Broadcasting. Healthyminds.org. (2007). â€Å"Psychiatric Effects of Media Violence.† Retrieved May 24, 2007, from . MAN. (2007). Research on the effects of media violence. Retrieved May 24, 2007, from . Potter, W. J. (1999). On Media Violence, Thousand Oaks: Sage. Weaver, C. K. and C. Carter. (2006), Critical Readings: Violence and the Media, Maidenhead: Open University Press.      

My philosophy for advanced practice nursing Essay

My philosophy for advanced practice nursing (APN) is an extension of the philosophy of my nursing practice. I plan to form a partnership with my patients in which compassionate, holistic, evidence based care will lead to the patient maintaining optimal health and wellness. Advance Practice Nurses focus entirely on the patient by compassionately addressing every aspect of the patient’s needs. My goal is to educate and encourage the patient to become responsible for his/her health by working diligently with the healthcare team. An APN’s primary focus should be to address and remove the underlying cause of illness rather than to merely alleviate the presenting symptoms. This can be done by addressing underlying issues that can hinder the healing process and establish a plan to remove these obstacles in order to promote holistic healing. I value treating the whole patient (emotional, genetic, environmental, social, physical, spiritual, and other factors) and offering means of wellness in conjunction with traditional options (Nightingale, 1954). Nurse Practitioners provide the patient with a holistic care that includes not only exercise, nutrition, environment, and stressors, but also considers the client’s cultural world view (Dossey, 2010). When this approach is taken, each patient is able to experience an individualized plan of treatment. As I step out of the role of bedside nurse and embrace the role of an APN, I look forward to the additional responsibilities of diagnosing and treating patients which will afford me a greater role in the improvement of my patient’s health. This advanced role in designing and implementing plans of treatment empowers the APN to provide complete patient care. The APN role also allows me the opportunity to educate my patients, their families and the community on measures to improve health and prevent future illnesses. I look forward to advancing as a professional because, as I do so, I can make a difference by implementing and improving patient care and teaching others. References Dossey, B. (2010). Holistic nursing: from Florence Nightingale’s historical legacy to 21st-century global nursing. Alternative Therapies in Health and Medicine, 16(5), 14-16. Nightingale, F. (1954). Notes on nursing: What it is and what it is not. In L.R. Seymer (Ed.), selected writings of Florence Nightingale (p.123-220). New York: Macmillan. (Original work published 1859).

How to Write a Definition Essay on the Biocultural Approach to the Climate Change

How to Write a Definition Essay on the Biocultural Approach to the Climate Change If you are tasked with writing a definition essay on the biocultural approach to the climate change, your goal is to use the aforementioned topic and its contents in support of a unique definition of one word of your choosing (don’t forget to look at the suggested topics on the biocultural approach to the climate change). The word can be an abstract, broadly sweeping concept which you define based on the writings or book you have studied in class. For example: you might want to define â€Å"sustainability†. This word is one which you are likely to come across in your readings multiple times, but is something tangentially related to the topic of climate change. When studying the climate change and its impact, you might reflect upon sustainable options for improvement in different biocultural areas, or how people can incorporate sustainable growth which mitigates the negative impact of climate change. But with that, your goal is to focus your entire essay on defining that single word in a unique fashion. The Pre-Writing Phase When defining your word, you should: 1) Think creatively, think about all possible explanations or definitions of the word. Reflect upon how you saw it used in your reading, or how multiple authors have used it in their publications. 2) Review different authors who have covered that topic so as to glean a better, more comprehensive idea or understanding about the word (you can also check out our facts on the biocultural approach to the climate change to have a better grasp on the definition). 3) Reflect upon what it means to you personally. Remember that your goal here is not to present a dictionary definition of the word but rather, to create your own definition supported by evidence. For example: if you have selected â€Å"sustainability†, take a moment to reflect upon what that means to you. Does sustainability mean that an action or set of actions can be repeated by many people across a village, and therefore has to be something simple and teachable? Does sustainability mean something that mitigates negative impacts wrought on certain environments, such as crop rotation to bring back into the soil elements which were taken out during the last harvest? Does sustainability mean something that coincides with Mother Nature as she has been since before mankind, and therefore translate directly into farming or dietary practices that coincide with the natural cycles of the Earth? The Writing Phase Once you have reflected and done your research, it is time to sit down and draft your outline. The outline can take any form you choose. You might consider a bullet point list with short phrases to guide your writing or a Roman numeral list that has comprehensive sentences, topics, and transitions. Figure out what organizational method works best for you and use this as a time to play around with the organization of your piece until you find what best suits your subject matter. Once that is done, you just have to write out the draft based on your outline. The Post-Writing Phase With the draft ready, it is time to edit the content, organization, and flow. This is a big picture type of review which should be followed by a red-pen style proofread for sentence level errors.

This is history...this is history on drugs Essay

This is history...this is history on drugs - Essay Example It is also a contributor to the economy. Historical sites and archeology have attracted tourist and thus pumping cash into the country’s economy. History has boosted scientific growth since it is from the past that advancements are made to better human life. It is from history that a country is able to know is origin and independence. How the country evolved and split into its various states. Nowadays in school, history is an uphill task and most students do not like it. The students have the mentality that the course is very wide and difficult. Loewen records that current history analysis focuses more on the good and pays little attention to the wrong. He quotes President Wilson to whom many students attribute women suffrage. Though this is true, President Wilson led the country to war during Palmers raid. He says more harm took place when Wilson secretly funded the invasion of Russia thus controlling the security of the state. Wilson linked with Japanese invasion to invade Vladivostok and set up an anticommunist government while maintaining the war fronts. Loewen says,’ no one of the twelve American history textbooks in my original sample ever mentioned it.’ He compares American history books to Russian books and concludes that the latter are more descriptive in their approach. In the past, Wilson also wanted to build links and promote boarder security wi th neighboring Latin countries. The idea was noble and favored both countries to grow economically and have a larger security backing. Current books however shy from showing the wrongdoing of Wilson. It was through this that the invasion occurred. American books try to make individuals to seem like heroes. It is through this that most books shy away from documenting the outcome of the 1920 election (Loewen 17). Idolizing individuals led to the development of new terminologies owing to their acts. Christopher Columbus voyages are said to be the cause of

Truth, Jacobs or Tubman Essay Example | Topics and Well Written Essays - 1250 words

Truth, Jacobs or Tubman - Essay Example Her firm faith in God is the major force that helped her reach spiritual heights winning many friends and admirers among the noblest and the best of the dominant race. Her mother’s teaching had a profound effect on her. It sowed the seeds of tolerance, strong ethical attitude and a deep faith in God. As a child she was told that God lives in the sky and whenever she was beaten, or cruelly treated, she was guided to seek the help of Him1, who will always hear and help her. Her mother taught her children to kneel and say the Lord’s Prayer. They were entreated to refrain from lying and stealing, and were trained to obey their masters. She had a revelation that there was no place where God was not. She considered it a sin to forget her Almighty friend who is ever present to help her in times of trouble. She plainly saw there was no place, not even in hell, where he was not. She was awe struck at his bigness and it frightened her. At the same time she became aware of her and wanted to talk with God. But she was terrified by that idea as He may extinguish her with his look. She felt she badly needed a spokesperson to represent her case to God. But who would plead for her without letting God know that it had come from her? She saw a bright vision getting into a distinct form beaming with the beauty of holiness and radiant love. She was confused. The figure in vision was intimate to her, yet it was not so familiar. Her mind was restless like the agitated waters in the sea. Her heart was haunted with the question who he is. The vision got more and more distinct. She realized it was Jesus. Jesus appeared to her in the form of vision. In the beginning, Jesus appeared as a savior and like any other eminent man who is very loving and good. She says she believes Jesus is the same spirit that was in our first parents, Adam and Eve, in the beginning, when they came from the hand of their Creator. According to Painter, Truth refashioned